Misery Signals was formed after the break-ups of several bands, those bands being 7 Angels 7 Plagues, Hamartia and Compromise. Having played temporarily with 7 Angels 7 Plagues, former Compromise vocalist Jesse Zaraska was approached by Ryan Morgan and Kyle Johnson for a new project, which would become Misery Signals. Jeff Aust from Hamartia at that point filled out the lineup on second guitar, and Ryan Morgan's brother Branden took the drums. Aust soon left the band and has since gone on to join With Honor, he was replaced by Stu Ross - a friend of Jesse Zaraska's from Edmonton, Alberta.

The band eventually signed to New Jersey's Ferret Music, releasing their first full-length album, Of Malice and the Magnum Heart. After extensive touring, Zaraska decided to leave the band to focus on a smaller, less aggressive project named Sleeping Girl, at which point the rest of the band decided to put up an instrumental song on their MySpace page, encouraging anyone who wanted to take over the spot of vocalist to record their own voice over the instrumental and e-mail it to the band. This was the way they found new vocalist Karl Schubach, with whom they recorded their album,Mirrors. Misery Signals have finished recording songs for their new album due to be released July 22nd, 2008 entitled Controller. The album is being recorded by Devin Townsend and released by Ferret Music.